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Classification and external resources
File:Diseases of Swine 25-5.png
Foot-and-mouth disease. Acantholysis in a sample of a skin vesicle. Necrosis of the stratum spinosum can be observed, and keratinocytes floating in the vesicular fluid (spongiosa).
ICD-10 L11.9 (ILDS L11.900)

Acantholysis is the loss of intercellular connections resulting in loss of cohesion between keratinocytes[1], seen in diseases such as pemphigus vulgaris.[2] It is absent in bullous pemphigoid, making it useful for differential diagnosis.

This histological feature is also seen in herpes simplex infections (HSV 1 and 2).

See also

  • Skin lesion
  • Skin disease
  • List of cutaneous conditions


  1. Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) Robbins & Cotran Pathologic Basis of Disease (7th ed.). Saunders. Page 1230. ISBN 0-7216-0187-1.
  2. Medical Dictionary Entry


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