Jump to: navigation, search

Junctional epidermolysis bullosa (veterinary medicine)

File:Belgisch trekpaard.jpg
The Belgian Draft Horse is one of the more common breeds in which JEB occurs

Junctional epidermolysis bullosa (JEB), or Epitheliogenesis Imperfecta (EI), is a genetic disorder found in horses. Although affected foals appear initially to be born healthy, clinical signs appear quickly, and they are usually euthanized not long after birth.

Breeds affected

JEB has documented in Belgian drafts, American Cream Draft, Breton drafts, Comtois, and American Saddlebreds. Of these horses, 12% of Belgians and 4% of Saddlebreds are thought to carry the disorder.

Symptoms, Causes, and Prognosis

JEB causes defect in the action of the protein needed to connect the dermis to the epidermis. This produces many symptoms, including:

  • hair and skin loss, especially over pressure points (hock, elbows and stifle, fetlocks, and hip). These patches of skin loss grow over time.
  • sloughing of the hoof, and ulcers around the coronary band
  • oral ulcers, especially around the teeth
  • incisors in at birth

There is no known treatment. Foals are usually euthanized after diagnosis, due to the pain associated with the disease. Those that are not euthanized usually die of infection within 2 weeks.


"Testing for Genetic Diseases." Equus 353. pp 42–43.


Premier Equine Classifieds


Subscribe to our newsletter and keep abreast of the latest news, articles and information delivered directly to your inbox.

Did You Know?

Modern horse breeds developed in response to a need for "form to function", the necessity to develop certain physical characteristics in order to perform a certain type of work... More...

The Gypsy Cob was originally bred to be a wagon horse and pulled wagons or caravans known as Vardos; a type of covered wagon that people lived in... More...

Archaeological evidence indicates that the Arabian horse bloodline dates back 4,500 years. Throughout history, Arabian horses spread around the world by both war and trade.... More...

That the term "Sporthorse" is a term used to describe a type of horse rather than any particular breed... More...